Journal article
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
L Bransby, N Yassi, E Rosenich, R Buckley, QX Li, P Maruff, M Pase, YY Lim
Neurobiology of Aging | ELSEVIER SCIENCE INC | Published : 2024
Abstract
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report questionnaires and a neuropsychological battery. Cerebrospinal fluid levels of Aβ 1–42, total tau (t-tau), and phosphorylated tau (p-tau181) (Roche Elecsys), and MRI markers of hippocampal volume and total brain volume were obtained. Participants were classified as no/single domain risk (≤1 dom..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The Healthy Brain Project (healthybrainproject.org.au) is funded by the National Health and Medical Research Council (NHMRC) (GNT1158384, GNT1147465, GNT1111603, GNT1105576, GNT1104273, GNT1171816) , the Alzheimer's Association (AARG-17-591424, AARG-18-591358, AARG-19-643133) , the Dementia Australia Research Foundation, the Yulgilbar Alzheimer's Research Program, and the Charleston Conference for Alzheimer's Disease. L Bransby is supported by a Dementia Australia Research Foundation PhD Scholarship. YY Lim is supported by an NHMRC Career Development Fellowship (GNT1162645), and Emerging Leadership Grant (GNT2009550) . E Rosenich is supported by an Alzheimer's Association Research Fellowship (23AARF-1025519). RF Buckley is supported by an NIH K99-R00 award (K99AG061238) . MP Pase is supported by a Heart Foundation Future Leader Fellowship (GNT102052) .